Does early goal directed therapy in sepsis still hold relevance in low and middle-income countries?

Authors

Keywords:

Early goal directed therapy, EGDT, low and middle income countries, Sepsis

Abstract

Abstract

The efficacy of early goal directed therapy in improving outcomes has been questioned in few recent studies. But, does that hold true for low and middle income countries like Nepal? This editorial expresses the views of the editors on the usual care of sepsis patients and early goal directed therapy in resource limited settings.

Author Biographies

Diptesh Aryal, Tribhuvan University Teaching Hospital, Institute of Medicine

Lecturer, Department of Anesthesiology, TUTH, IOM

Apurb Sharma, Shahid Gangalal National Heart Centre: Kathmandu, Bagmati, Nepal

Head of the Department

References

1. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77. https://doi.org/10.1056/NEJMoa010307 [PMid:11794169]

2. Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, et al. Surviving Sepsis Campaign.The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010;38:367-74.https://doi.org/10.1097/CCM.0b013e3181cb0cdc [PMid:20035219]

3. Angus DC1, Barnato AE, Bell D, Bellomo R, Chong CR, Coats TJ, et al. A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators. Intensive Care Med 2015;41:1549-60. https://doi.org/10.1007/s00134-015-3822-1 [PMid:25952825]

4. S Koirala, A Ghimire, A Sharma, B Bhattarai. ICU admission and outcomes in a community-based tertiary care hospital: an audit of one year. Health Renaissance 2011;9:83-7. https://doi.org/10.3126/hren.v9i2.4978

5. Phua J, Koh Y, Du B, Tang YQ, Divatia JV, Tan CC, et al. Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ 2011342:d3245. https://doi.org/10.1136/bmj.d3245

Downloads

Published

2017-06-28

How to Cite

Aryal, D., & Sharma, A. (2017). Does early goal directed therapy in sepsis still hold relevance in low and middle-income countries?. Journal of Society of Anesthesiologists of Nepal, 4(1), 1-2. Retrieved from http://www.jsan.org.np/jsan/index.php/jsan/article/view/170

Most read articles by the same author(s)